INJURY AS A CAUSATIVE FACTOR IN CANCER

AGE proteins as a causative factor in Alzheimer's Disease

The reaction between reducing sugars and protein free amines, known as the Maillar reaction results in the formation of advanced glycation endproducts (AGEs). AGE modification changes the structure of proteins to amyloid cross-beta structure. These protein structures can activate receptors known as RAGE on glial cells (microglia and astrocytes), and induce the expression of inducible nitric oxi...

AGE proteins as a causative factor in Alzheimer's Disease

The reaction between reducing sugars and protein free amines, known as the Maillar reaction results in the formation of advanced glycation endproducts (AGEs). AGE modification changes the structure of proteins to amyloid cross-beta structure. These protein structures can activate receptors known as RAGE on glial cells (microglia and astrocytes), and induce the expression of inducible nitric oxi...

Appraisal of dietary fat as a causative factor in atherogenesis.

This document attempts to evaluate the strengths of the associations between dietary fat and the genesis of atherosclerosis; the kinds of evidence on which these associations are based; and the risks and benefits caused by changing the quantity and quality of dietary fat in the American diet. The role of dietary fat will be evaluated herein as a factor independent of such other putative dietary...

Troponin as a Prognostic Factor of Brain Injury in Military Field Hospitals

Inflammation, a Key Factor in Cancer Ambush

Inflammatory condition is the consequence of defensive mechanism of immune system against viral and bacterial infection, tissue injury, UV radiation, stress and etc. Persistently acute inflammation leads to chronic phase which is characterized by production of pro-inflammatory mediators from T cells. These molecules (e.g. IL-6, TNF-&alpha, IL-1&beta and IL-17) are mostly pleiotropic cytokines i...